Da-Yong Lu*, Peng-Peng Zhu, Hong-Ying Wu, Nagendra Sastry Yarla, Bin Xu and Ting-Ren Lu Pages 206 - 212 ( 7 )
Introduction: Suicide is still a major event of human mortality worldwide. Yet human suicide prediction, prevention and therapeutic systems at this moment are generally ineffective in the clinic. No diagnostic system is reliable for significantly suicidal prevention and mortality reduction. As a result, human suicide etiopathologic investigation (especially at genetic/molecular levels in the clinical settings) is quite necessary. In order to boost human suicide researches, emerging human suicide diagnostic/treatment study will be transformed from clinical symptom observations into new generations of candidate drug targets and therapeutics. To achieve this goal, associations between suicidal etiopathologic identification, genetic/bioinformatics-based diagnostics and putative drug targets must be exploited than ever before. After all, the interaction and relationships between environmental/ genetic/molecular clues and overall patient’s risk prediction (environmental influences and different therapeutic targets/types) should be found out.
Conclusion: In the future, effective clinical suicide prediction, prevention and therapeutic systems can be established via scientific expeditions and causality discovery.
Bioinformatics, clinical pharmacology, drug development, environmental influence, human genome, human suicide, mental disorders, neural pathogenesis.
Shanghai University, Shanghai 200444, Neural Unit, National Institute of Neurological Disorders (NINDS), NIH, Maryland, MD, Shanghai University, Shanghai 200444, Divisions of Biochemistry & Chemistry, City University of New York School of Medicine, 160 Convent Avenue, New York, NY10031, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Shi, Shanghai University, Shanghai 200444