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Pharmacological Approach of Pistacia Vera Fruit to Assess Learning and Memory Potential in Chemically-Induced Memory Impairment in Mice

[ Vol. 19 , Issue. 2 ]

Author(s):

Satyam Singh, Dharamveer and Mayank Kulshreshtha*   Pages 125 - 132 ( 8 )

Abstract:


Objective: The present study was designed to investigate the potential of Pistacia vera (P. vera) fruits in experimental memory impairments in mice.

Material & Methods: Memory impairment was induced in Swiss Albino mice by Scopolamine (0.4mg mg/kg. i.p). Animals were divided into five separate groups of six animals in each, positive control received CMC as vehicle, negative control group received Scopolamine with vehicle, and standard was given donepezil (5mg/kg i.p) with Scopolamine. Ethanolic extract of P.vera (EEPV) at doses of 200mg/kg & 400mg/kg p.o were administered to group test1 & test 2 respectively along with scopolamine. Elevated plus maze, passive avoidance paradigms and Morris water maze were used as exteroceptive behavioral models to access learning and memory activity. Transfer latency, step down latency and escape latency were parameter checked for elevated plus maze, passive avoidance paradigm, morris water maze. Thereafter lipid peroxidation test, glutathione level, catalase activities were estimated in homogenized brain of mice.

Results: Pretreatment of mice with EEPV (200mg/kg & 400mg/kg) significantly reduced scopolamine induced amnesia. Increase in escape latency in Morris water maze, whereas in elevated plus maze administration of extract produced significantly decrease in transfer latency and significantly increase in step down latency was shown by animals whereas lipid peroxidation and glutathione level was markedly lowered in animals of test 1 & test 2 as compared to negative control group, which was indicative of cognitive improvement.

Conclusion: P.vera fruit extract demonstrated to improve cognitive process by enhancing memory in different experimental paradigm such as elevated plus maze, passive avoidance and morris water maze when administered orally. The decreased level of lipid peroxidation and increased Catalase activity through its antioxidant power of P. vera comprised of tannins, saponins, flavonoids and alkaloids. Hence it would be worthwhile to explore the potential of this plant in the management of memory disorders.

Pharmacological, Approach, of, Pistacia, Vera, Fruit, to, Assess, Learning, and, Memory, Potential, in, Chemically-Induced, Memory, Impairment, in, Mice,

Affiliation:

School of Pharmacy, Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow227105, Uttar Pradesh, School of Pharmacy, Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow227105, Uttar Pradesh, School of Pharmacy, Babu Banarasi Das University, Babu Banarasi Das City, Faizabad Road, Chinhat, Lucknow227105, Uttar Pradesh



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